The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes.
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ABSTRACT:
SUBMITTER: Capewell P
PROVIDER: S-EPMC5065312 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes.
Capewell Paul P Cren-Travaillé Christelle C Marchesi Francesco F Johnston Pamela P Clucas Caroline C Benson Robert A RA Gorman Taylor-Anne TA Calvo-Alvarez Estefania E Crouzols Aline A Jouvion Grégory G Jamonneau Vincent V Weir William W Stevenson M Lynn ML O'Neill Kerry K Cooper Anneli A Swar Nono-Raymond Kuispond NK Bucheton Bruno B Ngoyi Dieudonné Mumba DM Garside Paul P Rotureau Brice B MacLeod Annette A
eLife 20160922
The role of mammalian skin in harbouring and transmitting arthropod-borne protozoan parasites has been overlooked for decades as these pathogens have been regarded primarily as blood-dwelling organisms. Intriguingly, infections with low or undetected blood parasites are common, particularly in the case of Human African Trypanosomiasis caused by <i>Trypanosoma brucei gambiense</i>. We hypothesise, therefore, the skin represents an anatomic reservoir of infection. Here we definitively show that su ...[more]
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