Ontology highlight
ABSTRACT:
SUBMITTER: Theunissen TW
PROVIDER: S-EPMC5065525 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Theunissen Thorold W TW Friedli Marc M He Yupeng Y Planet Evarist E O'Neil Ryan C RC Markoulaki Styliani S Pontis Julien J Wang Haoyi H Iouranova Alexandra A Imbeault Michaël M Duc Julien J Cohen Malkiel A MA Wert Katherine J KJ Castanon Rosa R Zhang Zhuzhu Z Huang Yanmei Y Nery Joseph R JR Drotar Jesse J Lungjangwa Tenzin T Trono Didier D Ecker Joseph R JR Jaenisch Rudolf R
Cell stem cell 20160714 4
Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency. Here we propose a set of molecular criteria for evaluating the naive human pluripotent state by comparing it to the human embryo. We show that transcription of transposable elements provides a sensitive measure of the concordance between pluripotent stem cells and early human development. We also show that induc ...[more]