Ontology highlight
ABSTRACT:
SUBMITTER: Beck MW
PROVIDER: S-EPMC5065625 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nature communications 20161013
The absence of effective therapeutics against Alzheimer's disease (AD) is a result of the limited understanding of its multifaceted aetiology. Because of the lack of chemical tools to identify pathological factors, investigations into AD pathogenesis have also been insubstantial. Here we report chemical regulators that demonstrate distinct specificity towards targets linked to AD pathology, including metals, amyloid-β (Aβ), metal-Aβ, reactive oxygen species, and free organic radicals. We obtaine ...[more]