Ontology highlight
ABSTRACT:
SUBMITTER: Saha S
PROVIDER: S-EPMC5065628 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nature communications 20161013
WNT/β-catenin signalling is crucial for intestinal homoeostasis. The intestinal epithelium and stroma are the major source of WNT ligands but their origin and role in intestinal stem cell (ISC) and epithelial repair remains unknown. Macrophages are a major constituent of the intestinal stroma. Here, we analyse the role of macrophage-derived WNT in intestinal repair in mice by inhibiting their release using a macrophage-restricted ablation of Porcupine, a gene essential for WNT synthesis. Such Po ...[more]