Fe-S cluster biogenesis in Gram-positive bacteria: SufU is a zinc-dependent sulfur transfer protein.
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ABSTRACT:
SUBMITTER: Selbach BP
PROVIDER: S-EPMC5065719 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
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Fe-S cluster biogenesis in Gram-positive bacteria: SufU is a zinc-dependent sulfur transfer protein.
Selbach Bruna P BP Chung Alexander H AH Scott Aubrey D AD George Simon J SJ Cramer Stephen P SP Dos Santos Patricia C PC
Biochemistry 20131223 1
The biosynthesis of Fe-S clusters in Bacillus subtilis and other Gram-positive bacteria is catalyzed by the SufCDSUB system. The first step in this pathway involves the sulfur mobilization from the free amino acid cysteine to a sulfur acceptor protein SufU via a PLP-dependent cysteine desulfurase SufS. In this reaction scheme, the formation of an enzyme S-covalent intermediate is followed by the binding of SufU. This event leads to the second half of the reaction where a deprotonated thiol of Su ...[more]
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