Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits.
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ABSTRACT:
SUBMITTER: Chakrabortee S
PROVIDER: S-EPMC5066306 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits.
Chakrabortee Sohini S Byers James S JS Jones Sandra S Garcia David M DM Bhullar Bhupinder B Chang Amelia A She Richard R Lee Laura L Fremin Brayon B Lindquist Susan S Jarosz Daniel F DF
Cell 20160929 2
Prions are a paradigm-shifting mechanism of inheritance in which phenotypes are encoded by self-templating protein conformations rather than nucleic acids. Here, we examine the breadth of protein-based inheritance across the yeast proteome by assessing the ability of nearly every open reading frame (ORF; ∼5,300 ORFs) to induce heritable traits. Transient overexpression of nearly 50 proteins created traits that remained heritable long after their expression returned to normal. These traits were b ...[more]
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