Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Domenech G
PROVIDER: S-EPMC5067282 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
López-Doménech Guillermo G Higgs Nathalie F NF Vaccaro Victoria V Roš Hana H Arancibia-Cárcamo I Lorena IL MacAskill Andrew F AF Kittler Josef T JT
Cell reports 20161001 2
Correct mitochondrial distribution is critical for satisfying local energy demands and calcium buffering requirements and supporting key cellular processes. The mitochondrially targeted proteins Miro1 and Miro2 are important components of the mitochondrial transport machinery, but their specific roles in neuronal development, maintenance, and survival remain poorly understood. Using mouse knockout strategies, we demonstrate that Miro1, as opposed to Miro2, is the primary regulator of mitochondri ...[more]