Ontology highlight
ABSTRACT:
SUBMITTER: Vora J
PROVIDER: S-EPMC5067686 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Vora J J Seufert J J Solberg H H Kinduryte O O Johansen T T Hollander P P
Diabetes, obesity & metabolism 20160208 7
We examined insulin antibody formation in patients with type 1 (T1D) or type 2 diabetes (T2D) treated with once-daily insulin degludec (IDeg) or insulin glargine (IGlar) to evaluate the impact of antibody formation on efficacy and safety. Insulin antibodies were measured using subtraction radioimmunoassays in six phase IIIa clinical trials using IDeg (n = 2250) and IGlar (n = 1184). Spearman's correlation coefficient was used to evaluate associations between cross-reacting antibodies and change ...[more]