Ontology highlight
ABSTRACT:
SUBMITTER: Chong SZ
PROVIDER: S-EPMC5068243 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Chong Shu Zhen SZ Evrard Maximilien M Devi Sapna S Chen Jinmiao J Lim Jyue Yuan JY See Peter P Zhang Yiru Y Adrover José M JM Lee Bernett B Tan Leonard L Li Jackson L Y JL Liong Ka Hang KH Phua Cindy C Balachander Akhila A Boey Adrian A Liebl David D Tan Suet Mien SM Chan Jerry K Y JK Balabanian Karl K Harris John E JE Bianchini Mariaelvy M Weber Christian C Duchene Johan J Lum Josephine J Poidinger Michael M Chen Qingfeng Q Rénia Laurent L Wang Cheng-I CI Larbi Anis A Randolph Gwendalyn J GJ Weninger Wolfgang W Looney Mark R MR Krummel Matthew F MF Biswas Subhra K SK Ginhoux Florent F Hidalgo Andrés A Bachelerie Françoise F Ng Lai Guan LG
The Journal of experimental medicine 20161010 11
It is well established that Ly6C<sup>hi</sup> monocytes develop from common monocyte progenitors (cMoPs) and reside in the bone marrow (BM) until they are mobilized into the circulation. In our study, we found that BM Ly6C<sup>hi</sup> monocytes are not a homogenous population, as current data would suggest. Using computational analysis approaches to interpret multidimensional datasets, we demonstrate that BM Ly6C<sup>hi</sup> monocytes consist of two distinct subpopulations (CXCR4<sup>hi</sup> ...[more]