Ontology highlight
ABSTRACT:
SUBMITTER: Pezza A
PROVIDER: S-EPMC5068291 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Pezza Alejandro A Pontel Lucas B LB López Carolina C Soncini Fernando C FC
Proceedings of the National Academy of Sciences of the United States of America 20160927 41
Copper homeostasis is essential for bacterial pathogen fitness and infection, and has been the focus of a number of recent studies. In Salmonella, envelope protection against copper overload and macrophage survival depends on CueP, a major copper-binding protein in the periplasm. This protein is also required to deliver the metal ion to the Cu/Zn superoxide dismutase SodCII. The Salmonella-specific CueP-coding gene was originally identified as part of the Cue regulon under the transcriptional co ...[more]