Ontology highlight
ABSTRACT:
SUBMITTER: Mechling AE
PROVIDER: S-EPMC5068324 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Mechling Anna E AE Arefin Tanzil T Lee Hsu-Lei HL Bienert Thomas T Reisert Marco M Ben Hamida Sami S Darcq Emmanuel E Ehrlich Aliza A Gaveriaux-Ruff Claire C Parent Maxime J MJ Rosa-Neto Pedro P Hennig Jürgen J von Elverfeldt Dominik D Kieffer Brigitte Lina BL Harsan Laura-Adela LA
Proceedings of the National Academy of Sciences of the United States of America 20160926 41
Connectome genetics seeks to uncover how genetic factors shape brain functional connectivity; however, the causal impact of a single gene's activity on whole-brain networks remains unknown. We tested whether the sole targeted deletion of the mu opioid receptor gene (Oprm1) alters the brain connectome in living mice. Hypothesis-free analysis of combined resting-state fMRI diffusion tractography showed pronounced modifications of functional connectivity with only minor changes in structural pathwa ...[more]