Ontology highlight
ABSTRACT:
SUBMITTER: Yan Z
PROVIDER: S-EPMC5068790 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Yan Zhenzhen Z Hu Bin B Huang Zhigang Z Zhong Ling L Guo Xiying X Weng Anxi A Xiao Feng F Zeng Wenping W Zhang Yan Y Ding Jiuping J Hou Panpan P
PloS one 20161018 10
Large-conductance Ca2+- and voltage-activated potassium (BK) channels are widely expressed in tissues. As a voltage and calcium sensor, BK channels play significant roles in regulating the action potential frequency, neurotransmitter release, and smooth muscle contraction. After associating with the auxiliary β2 subunit, mammalian BK(β2) channels (mouse or human Slo1/β2) exhibit enhanced activation and complete inactivation. However, how the β2 subunit modulates the Drosophila Slo1 channel remai ...[more]