Ontology highlight
ABSTRACT:
SUBMITTER: Mossman JA
PROVIDER: S-EPMC5068850 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Mossman Jim A JA Tross Jennifer G JG Li Nan N Wu Zhijin Z Rand David M DM
Genetics 20160824 2
The assembly and function of mitochondria require coordinated expression from two distinct genomes, the mitochondrial DNA (mtDNA) and nuclear DNA (nDNA). Mutations in either genome can be a source of phenotypic variation, yet their coexpression has been largely overlooked as a source of variation, particularly in the emerging paradigm of mitochondrial replacement therapy. Here we tested how the transcriptome responds to mtDNA and nDNA variation, along with mitonuclear interactions (mtDNA × nDNA) ...[more]