Ctr9, a Key Component of the Paf1 Complex, Affects Proliferation and Terminal Differentiation in the Developing Drosophila Nervous System.

ABSTRACT: The Paf1 protein complex (Paf1C) is increasingly recognized as a highly conserved and broadly utilized regulator of a variety of transcriptional processes. These include the promotion of H3K4 and H3K36 trimethylation, H2BK123 ubiquitination, RNA Pol II transcriptional termination, and also RNA-mediated gene silencing. Paf1C contains five canonical protein components, including Paf1 and Ctr9, which are critical for overall complex integrity, as well as Rtf1, Leo1, and Cdc73/Parafibromin(Hrpt2)/Hyrax. In spite of a growing appreciation for the importance of Paf1C from yeast and mammalian studies, there has only been limited work in Drosophila Here, we provide the first detailed phenotypic study of Ctr9 function in Drosophila We found that Ctr9 mutants die at late embryogenesis or early larva

SUBMITTER: Bahrampour S 

PROVIDER: S-EPMC5068944 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature