Ontology highlight
ABSTRACT:
SUBMITTER: Suryo Rahmanto A
PROVIDER: S-EPMC5069553 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Suryo Rahmanto Aldwin A Savov Vasil V Brunner Andrä A Bolin Sara S Weishaupt Holger H Malyukova Alena A Rosén Gabriela G Čančer Matko M Hutter Sonja S Sundström Anders A Kawauchi Daisuke D Jones David Tw DT Spruck Charles C Taylor Michael D MD Cho Yoon-Jae YJ Pfister Stefan M SM Kool Marcel M Korshunov Andrey A Swartling Fredrik J FJ Sangfelt Olle O
The EMBO journal 20160913 20
SOX9 is a master transcription factor that regulates development and stem cell programs. However, its potential oncogenic activity and regulatory mechanisms that control SOX9 protein stability are poorly understood. Here, we show that SOX9 is a substrate of FBW7, a tumor suppressor, and a SCF (SKP1/CUL1/F-box)-type ubiquitin ligase. FBW7 recognizes a conserved degron surrounding threonine 236 (T236) in SOX9 that is phosphorylated by GSK3 kinase and consequently degraded by SCF<sup>FBW</sup><sup> ...[more]