Ontology highlight
ABSTRACT: Unlabelled
Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.Conclusion
There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.
SUBMITTER: Hellstrom A
PROVIDER: S-EPMC5069563 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Hellström Ann A Ley David D Hansen-Pupp Ingrid I Hallberg Boubou B Löfqvist Chatarina C van Marter Linda L van Weissenbruch Mirjam M Ramenghi Luca A LA Beardsall Kathryn K Dunger David D Hård Anna-Lena AL Smith Lois E H LE
Acta paediatrica (Oslo, Norway : 1992) 20160308 6
<h4>Unlabelled</h4>Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.<h4>C ...[more]