Ontology highlight
ABSTRACT: Significance
Stem cells are limited as tissue replacements owing to rapid death induced in the hostile wound environment. It has been found that restricting epidermal growth factor (EGF) receptor signaling to the membrane provides a survival advantage. This report elucidates a method to tether EGF to bone induction material to improve the survival of mesenchymal stem cells/multipotent stromal cells in vivo.
SUBMITTER: Nuschke A
PROVIDER: S-EPMC5070502 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nuschke Austin A Rodrigues Melanie M Rivera Jaime J Yates Cecelia C Whaley Diana D Stolz Donna D Griffith Linda L Wells Alan A
Stem cells translational medicine 20160708 11
: Mesenchymal stem cells/multipotent stromal cells (MSCs) are attractive candidates for cell therapies owing to their ability to differentiate into many lineages. However, these cells often fail to survive when implanted into a harsh wound environment, limiting efficacy in vivo. To improve MSC survival, we previously found that tethered epidermal growth factor (tEGF) molecules that restrict epidermal growth factor receptor (EGFR) signaling to the cell surface provide resistance to death signals. ...[more]