Ontology highlight
ABSTRACT:
SUBMITTER: Hennigan K
PROVIDER: S-EPMC5070911 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Hennigan Kerrie K Conroy Paul J PJ Walsh Marie-Therese MT Amin Mohamed M Amin Mohamed M O'Kennedy Richard R Ramasamy Patmapriya P Gleich Gerald J GJ Siddiqui Zeshan Z Glynn Senan S McCabe Olive O Mooney Catherine C Harvey Brian J BJ Costello Richard W RW McBryan Jean J
Clinical immunology (Orlando, Fla.) 20160809
Eosinophils account for 1-3% of peripheral blood leukocytes and accumulate at sites of allergic inflammation, where they play a pathogenic role. Studies have shown that treatment with mepolizumab (an anti-IL-5 monoclonal antibody) is beneficial to patients with severe eosinophilic asthma, however, the mechanism of precisely how eosinophils mediate these pathogenic effects is uncertain. Eosinophils contain several cationic granule proteins, including Eosinophil Peroxidase (EPO). The main signific ...[more]