Ontology highlight
ABSTRACT:
SUBMITTER: Ahn D
PROVIDER: S-EPMC5070956 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Ahn Danielle D Peñaloza Hernán H Wang Zheng Z Wickersham Matthew M Parker Dane D Patel Purvi P Koller Antonius A Chen Emily I EI Bueno Susan M SM Uhlemann Anne-Catrin AC Prince Alice A
JCI insight 20161020 17
Adaptive changes in the genome of a locally predominant clinical isolate of the multidrug-resistant <i>Klebsiella pneumoniae</i> ST258 (KP35) were identified and help to explain the selection of this strain as a successful pulmonary pathogen. The acquisition of 4 new ortholog groups, including an arginine transporter, enabled KP35 to outcompete related ST258 strains lacking these genes. KP35 infection elicited a monocytic response, dominated by Ly6C<sup>hi</sup> monocytic myeloid-derived suppres ...[more]