Ontology highlight
ABSTRACT:
SUBMITTER: Adefurin A
PROVIDER: S-EPMC5071105 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Adefurin A A Ghimire L V LV Kohli U U Muszkat M M Sofowora G G GG Li C C Levinson R T RT Paranjape S Y SY Stein C M CM Kurnik D D
The pharmacogenomics journal 20160419 4
The alpha<sub>1B</sub> (α<sub>1B</sub>)-adrenergic receptors contribute to vasoconstriction in humans. We tested the hypothesis that variation in the ADRA1B gene contributes to interindividual variability and ethnic differences in adrenergic vasoconstriction. We measured dorsal hand vein responses to increasing doses of phenylephrine in 64 Caucasians and 41 African Americans and genotyped 34 ADRA1B variants. We validated findings in another model of catecholamine-induced vasoconstriction, the in ...[more]