Augmented oxidative stress and preserved vasoconstriction induced by hydrogen peroxide in coronary arteries in obesity: role of COX-2.

ABSTRACT:

Background and purpose

Oxidative stress plays a key role in the vascular and metabolic abnormalities associated with obesity. Herein, we assessed whether obesity can increase coronary vasoconstriction induced by hydrogen peroxide (H₂ O₂ ) and the signalling pathways involving COX-2 and superoxide (O₂^.- ) generation.

Experimental approach

Contractile responses to H₂ O₂ and O₂^.- generation were measured in coronary arteries from genetically obese Zucker rats (OZR) and compared to lean Zucker rats (LZR).

Key results

Both basal and H₂ O₂ -stimulated O₂^.- production were enhanced in coronary arteries from OZR, but H₂ O₂ -

SUBMITTER: Santiago E 

PROVIDER: S-EPMC5071563 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature