Stereotypic wheel running decreases cortical activity in mice.
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ABSTRACT:
SUBMITTER: Fisher SP
PROVIDER: S-EPMC5071642 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Stereotypic wheel running decreases cortical activity in mice.
Fisher Simon P SP Cui Nanyi N McKillop Laura E LE Gemignani Jessica J Bannerman David M DM Oliver Peter L PL Peirson Stuart N SN Vyazovskiy Vladyslav V VV
Nature communications 20161017
Prolonged wakefulness is thought to gradually increase 'sleep need' and influence subsequent sleep duration and intensity, but the role of specific waking behaviours remains unclear. Here we report the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somatosensory cortex in mice. We find that stereotypic wheel running is associated with a substantial reduction in firing rates among a large subpopulation of cortical neurons, especially at high speeds. Whe ...[more]
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