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Targeting Antibiotic Resistance.

ABSTRACT: Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even last-resort antibiotics have lost their power. In addition, industry pipelines for the development of novel antibiotics have run dry over the past decades. A recent world health day by the World Health Organization titled "Combat drug resistance: no action today means no cure tomorrow" triggered an increase in research activity, and several promising strategies have been developed to restore treatment options against infections by resistant bacterial pathogens.

SUBMITTER: Chellat MF

PROVIDER: S-EPMC5071768 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Targeting Antibiotic Resistance.

Chellat Mathieu F MF Raguž Luka L Riedl Rainer R

Angewandte Chemie (International ed. in English) 20160322 23

Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even last-resort antibiotics have lost their power. In addition, industry pipelines for th ...[more]

PMID: 27000559

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