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Molecular characterization of the first G24P[14] rotavirus strain detected in humans.


ABSTRACT: Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/2012/G24P[14], has a genomic constellation of G24-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3. The VP2, VP3, VP7 and NSP3 genes cluster phylogenetically with bovine strains. The other genes occupy mixed clades containing animal and human strains. Strain RVA/human-wt/USA/2012741499/2012/G24P[14] most likely is the product of interspecies transmission and reassortment events. This is the second report of the G24 genotype and the first report of the G24P[14] genotype combination in humans.

SUBMITTER: Ward ML 

PROVIDER: S-EPMC5072358 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Molecular characterization of the first G24P[14] rotavirus strain detected in humans.

Ward M Leanne ML   Mijatovic-Rustempasic Slavica S   Roy Sunando S   Rungsrisuriyachai Kunchala K   Boom Julie A JA   Sahni Leila C LC   Baker Carol J CJ   Rench Marcia A MA   Wikswo Mary E ME   Payne Daniel C DC   Parashar Umesh D UD   Bowen Michael D MD  

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20160526


Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/2012/G24P[14], has a genomic constellation of G24-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3. The VP2, VP3, VP7 and NSP3 genes cluster phylogenetically with bovine strains. The other genes occupy mixed clades containing animal and human strains. Strain RVA/  ...[more]

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