Ontology highlight
ABSTRACT:
SUBMITTER: Howard JK
PROVIDER: S-EPMC5074308 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20160419 23
The trans-o-hydroxybenzylidene pyruvate aldolase-catalysed reactions between fluoropyruvate and many (hetero)aromatic aldehydes yield aldol adducts without subsequent dehydration. Treatment of the reaction products with hydrogen peroxide yields the corresponding syn-configured α-fluoro β-hydroxy carboxylic acids which have >98 % ee. The overall chemoenzymatic approach, in which fluoropyruvate serves as a fluoroacetate equivalent, may be exploited in the synthesis of polar building blocks and fra ...[more]