Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans.

ABSTRACT:

Rationale

Obstructive sleep apnea is a common disorder associated with increased risk for cardiovascular disease, diabetes, and premature mortality. Although there is strong clinical and epidemiologic evidence supporting the importance of genetic factors in influencing obstructive sleep apnea, its genetic basis is still largely unknown. Prior genetic studies focused on traits defined using the apnea-hypopnea index, which contains limited information on potentially important genetically determined physiologic factors, such as propensity for hypoxemia and respiratory arousability.

Objectives

To define novel obstructive sleep apnea genetic risk loci for obstructive sleep apnea, we conducted genome-wide association studies of quantitative traits in Hispanic/Latino Americans from

SUBMITTER: Cade BE 

PROVIDER: S-EPMC5074655 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature