Ontology highlight
ABSTRACT:
SUBMITTER: Man SM
PROVIDER: S-EPMC5074697 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Man Si Ming SM Karki Rajendra R Sasai Miwa M Place David E DE Kesavardhana Sannula S Temirov Jamshid J Frase Sharon S Zhu Qifan Q Malireddi R K Subbarao RKS Kuriakose Teneema T Peters Jennifer L JL Neale Geoffrey G Brown Scott A SA Yamamoto Masahiro M Kanneganti Thirumala-Devi TD
Cell 20160929 2
The inflammasome is an intracellular signaling complex, which on recognition of pathogens and physiological aberration, drives activation of caspase-1, pyroptosis, and the release of the pro-inflammatory cytokines IL-1β and IL-18. Bacterial ligands must secure entry into the cytoplasm to activate inflammasomes; however, the mechanisms by which concealed ligands are liberated in the cytoplasm have remained unclear. Here, we showed that the interferon-inducible protein IRGB10 is essential for acti ...[more]