Ontology highlight
ABSTRACT:
SUBMITTER: Bremmer DN
PROVIDER: S-EPMC5075101 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Bremmer Derek N DN Bauer Karri A KA Pouch Stephanie M SM Thomas Keelie K Smith Debra D Goff Debra A DA Pancholi Preeti P Balada-Llasat Joan-Miquel JM
Antimicrobial agents and chemotherapy 20161021 11
We tested 76 extensively drug-resistant (XDR) Acinetobacter baumannii isolates by the checkerboard method using only wells containing serum-achievable concentrations (SACs) of drugs. Checkerboard results were correlated by time-kill assay and clinical outcomes. Minocycline-colistin was the best combination in vitro, as it inhibited growth in one or more SAC wells in all isolates. Patients who received a combination that inhibited growth in one or more SAC wells demonstrated better microbiologica ...[more]