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Multifunctional Cu_2-xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453.

ABSTRACT: Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu_2-XTe) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.

SUBMITTER: Poulose AC

PROVIDER: S-EPMC5075932 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Multifunctional Cu<sub>2-x</sub>Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453.

Poulose Aby Cheruvathoor AC Veeranarayanan Srivani S Mohamed M Sheikh MS Aburto Rebeca Romero RR Mitcham Trevor T Bouchard Richard R RR Ajayan Pulickel M PM Sakamoto Yasushi Y Maekawa Toru T Kumar D Sakthi DS

Scientific reports 20161024

Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu<sub>2-X</sub>Te) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-g ...[more]

PMID: 27775048

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