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Multifunctional Cu2-xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453.

ABSTRACT: Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu2-XTe) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.

SUBMITTER: Poulose AC 

PROVIDER: S-EPMC5075932 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Multifunctional Cu<sub>2-x</sub>Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453.

Poulose Aby Cheruvathoor AC   Veeranarayanan Srivani S   Mohamed M Sheikh MS   Aburto Rebeca Romero RR   Mitcham Trevor T   Bouchard Richard R RR   Ajayan Pulickel M PM   Sakamoto Yasushi Y   Maekawa Toru T   Kumar D Sakthi DS  

Scientific reports 20161024

Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu<sub>2-X</sub>Te) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-g  ...[more]

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