Dataset Information

Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: A meta-analysis.

ABSTRACT:

Objective

To determine associations between cerebral microbleed (CMB) burden with recurrent ischemic stroke (IS) and intracerebral hemorrhage (ICH) risk after IS or TIA.

Methods

We identified prospective studies of patients with IS or TIA that investigated CMBs and stroke (ICH and IS) risk during ≥3 months follow-up. Authors provided aggregate summary-level data on stroke outcomes, with CMBs categorized according to burden (single, 2-4, and ≥5 CMBs) and distribution. We calculated absolute event rates and pooled risk ratios (RR) using random-effects meta-analysis.

Results

We included 5,068 patients from 15 studies. There were 115/1,284 (9.6%) recurrent IS events in patients with CMBs vs 212/3,781 (5.6%) in patients without CMBs (pooled RR 1.8 for CMBs vs no CMBs; 95% confidence interval [CI] 1.4-2.5). There were 49/1,142 (4.3%) ICH events in those with CMBs vs 17/2,912 (0.58%) in those without CMBs (pooled RR 6.3 for CMBs vs no CMBs; 95% CI 3.5-11.4). Increasing CMB burden increased the risk of IS (pooled RR [95% CI] 1.8 [1.0-3.1], 2.4 [1.3-4.4], and 2.7 [1.5-4.9] for 1 CMB, 2-4 CMBs, and ≥5 CMBs, respectively) and ICH (pooled RR [95% CI] 4.6 [1.9-10.7], 5.6 [2.4-13.3], and 14.1 [6.9-29.0] for 1 CMB, 2-4 CMBs, and ≥5 CMBs, respectively).

Conclusions

CMBs are associated with increased stroke risk after IS or TIA. With increasing CMB burden (compared to no CMBs), the risk of ICH increases more steeply than that of IS. However, IS absolute event rates remain higher than ICH absolute event rates in all CMB burden categories.

SUBMITTER: Wilson D

PROVIDER: S-EPMC5075978 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Publications

Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: A meta-analysis.

Wilson Duncan D Charidimou Andreas A Ambler Gareth G Fox Zoe V ZV Gregoire Simone S Rayson Phillip P Imaizumi Toshio T Fluri Felix F Naka Hiromitsu H Horstmann Solveig S Veltkamp Roland R Rothwell Peter M PM Kwa Vincent I H VI Thijs Vincent V Lee Yong-Seok YS Kim Young Dae YD Huang Yining Y Wong Ka Sing KS Jäger Hans Rolf HR Werring David J DJ

Neurology 20160902 14

<h4>Objective</h4>To determine associations between cerebral microbleed (CMB) burden with recurrent ischemic stroke (IS) and intracerebral hemorrhage (ICH) risk after IS or TIA.<h4>Methods</h4>We identified prospective studies of patients with IS or TIA that investigated CMBs and stroke (ICH and IS) risk during ≥3 months follow-up. Authors provided aggregate summary-level data on stroke outcomes, with CMBs categorized according to burden (single, 2-4, and ≥5 CMBs) and distribution. We calculated ...[more]

PMID: 27590288

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Dataset Information

Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: A meta-analysis.

Objective

Methods

Results

Conclusions

Publications

Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: A meta-analysis.

Similar Datasets

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