Unknown

Dataset Information

0

Clinical significance and prognostic value of TRIM24 expression in esophageal squamous cell carcinoma.


ABSTRACT: Tripartite motif-containing 24 (TRIM24), a member of the transcription intermediary factor 1 family, is defined as a co-regulator with several nuclear receptors, such as RAR?. TRIM24 has been reported to be involved in many cancers. In this study, we aimed to investigate the expression pattern and prognostic significance of TRIM24 and its relationship with RAR? in esophageal squamous cell cancer (ESCC). Both mRNA and protein expression levels of TRIM24 were found to be significantly decreased in ESCC, as judged by qRT-PCR and western blot. Immunohistochemistry staining shows that the reduced TRIM24 protein is associated with lymph node metastasis (P=0.024), advance pathological TNM (pTNM) stage (P=0.046) and recurrence/metastasis (P=0.001). Upregulated TRIM24 protein predicts longer overall survival and disease-free survival (both P<0.001) and is an independent predictor for good prognosis (HR, 0.519; 95%CI, 0.341-0.788; P=0.002). TRIM24 expression has been proven remarkably to improve prediction of survival of pTNM stage in ESCC patients, especially in stage I and II. However, no significant relationship was found between TRIM24 and RAR? expression levels. In conclusion, reduced TRIM24 protein is associated with poor survival in ESCC patients, suggesting TRIM24 protein is a potential prognostic biomarker for ESCC.

SUBMITTER: Chi J 

PROVIDER: S-EPMC5076458 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Clinical significance and prognostic value of TRIM24 expression in esophageal squamous cell carcinoma.

Chi Jun J   Yang Qing Q   Xie Xiao-Feng XF   Yang Xian-Zi XZ   Zhang Mei-Yin MY   Wang Hui-Yun HY   Xu Guo-Liang GL  

Aging 20160901 9


Tripartite motif-containing 24 (TRIM24), a member of the transcription intermediary factor 1 family, is defined as a co-regulator with several nuclear receptors, such as RARα. TRIM24 has been reported to be involved in many cancers. In this study, we aimed to investigate the expression pattern and prognostic significance of TRIM24 and its relationship with RARα in esophageal squamous cell cancer (ESCC). Both mRNA and protein expression levels of TRIM24 were found to be significantly decreased in  ...[more]

Similar Datasets

| S-EPMC5384754 | biostudies-literature
| S-EPMC10470706 | biostudies-literature
| S-EPMC3599647 | biostudies-literature
| S-EPMC6779144 | biostudies-literature
| S-EPMC4307685 | biostudies-literature
| S-EPMC7282189 | biostudies-literature
| S-EPMC8353899 | biostudies-literature
| S-EPMC7748917 | biostudies-literature
| S-EPMC7281421 | biostudies-literature
| S-EPMC6277627 | biostudies-literature