Molecular Mechanisms of Enzyme Activation by Monovalent Cations.
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ABSTRACT:
SUBMITTER: Gohara DW
PROVIDER: S-EPMC5076497 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Molecular Mechanisms of Enzyme Activation by Monovalent Cations.
Gohara David W DW Di Cera Enrico E
The Journal of biological chemistry 20160726 40
Regulation of enzymes through metal ion complexation is widespread in biology and underscores a physiological need for stability and high catalytic activity that likely predated proteins in the RNA world. In addition to divalent metals such as Ca<sup>2+</sup>, Mg<sup>2+</sup>, and Zn<sup>2+</sup>, monovalent cations often function as efficient and selective promoters of catalysis. Advances in structural biology unravel a rich repertoire of molecular mechanisms for enzyme activation by Na<sup>+</ ...[more]
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