Ontology highlight
ABSTRACT:
SUBMITTER: Richard J
PROVIDER: S-EPMC5076506 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Richard Jessica J Kim Elizabeth D ED Nguyen Hoang H Kim Catherine D CD Kim Sunyoung S
The Journal of biological chemistry 20160808 40
How signals between the kinesin active and cytoskeletal binding sites are transmitted is an open question and an allosteric question. By extracting correlated evolutionary changes within 700+ sequences, we built a model of residues that are energetically coupled and that define molecular routes for signal transmission. Typically, these coupled residues are located at multiple distal sites and thus are predicted to form a complex, non-linear network that wires together different functional sites ...[more]