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Antagonizing programmed death-1 and programmed death ligand-1 as a therapeutic approach for gastric cancer.

ABSTRACT: Malignant tumor cells are equipped with mechanisms that can help them escape the surveillance by host immune system. Immune checkpoint molecules can transduce coinhibitory signals to immunocompetent cells and exert immunosuppressive roles in antitumor immunity. Programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) are the two important checkpoint molecules with great potential in targeted cancer therapy. Several antibodies targeting PD-1 and PD-L1 have been approved for clinical use. In this review, we focus on the recent development of targeting PD-1 and PD-L1 in gastric cancer (GC) therapy.

SUBMITTER: Liu X

PROVIDER: S-EPMC5076768 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Antagonizing programmed death-1 and programmed death ligand-1 as a therapeutic approach for gastric cancer.

Liu Xiaojun X Yang Zhongxia Z Latchoumanin Olivier O Qiao Liang L

Therapeutic advances in gastroenterology 20160721 6

Malignant tumor cells are equipped with mechanisms that can help them escape the surveillance by host immune system. Immune checkpoint molecules can transduce coinhibitory signals to immunocompetent cells and exert immunosuppressive roles in antitumor immunity. Programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) are the two important checkpoint molecules with great potential in targeted cancer therapy. Several antibodies targeting PD-1 and PD-L1 have been approved for clinical use. I ...[more]

PMID: 27803740

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