Ontology highlight
ABSTRACT:
SUBMITTER: Molinaro P
PROVIDER: S-EPMC5076784 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20151023 10
Three different Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) isoforms, NCX1, NCX2, and NCX3, are expressed in brain where they play a relevant role in maintaining Na<sup>+</sup> and Ca<sup>2+</sup> homeostasis. Although the neuroprotective roles of NCX2 and NCX3 in stroke have been elucidated, the relevance of NCX1 is still unknown because of embryonic lethality of its knocking-out, heart dysfunctions when it is overexpressed, and the lack of selectivity in currently available drugs. To overco ...[more]