Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC5078017 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Liu Liping L Yang Chenglin C Shen Jianfei J Huang Liyan L Lin Weixuan W Tang Hailing H Liang Wenhua W Shao Wenlong W Zhang Haibo H He Jianxing J
Oncotarget 20160501 22
Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABRA3 is reportedly upregulated in lung cancer. Herein, we show that high GABRA3 protein expression in lung adenocarcinoma correlated positively with disease stage, lymphatic metastasis status and poor patient survival. In addition, GABRA3 induced MMP-2 and MMP-9 expression through activation of the JNK/AP-1 signaling pathway, which enhanced lymphatic metastasis by lung adenocarcinoma ...[more]