Ontology highlight
ABSTRACT:
SUBMITTER: Bai DS
PROVIDER: S-EPMC5078065 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Bai Dou-Sheng DS Wu Chao C Yang Liu-Xiao LX Zhang Chi C Zhang Peng-Fei PF He Yi-Zhou YZ Cai Jia-Bin JB Song Zheng-Ji ZJ Dong Zhao-Ru ZR Huang Xiao-Yong XY Ke Ai-Wu AW Shi Guo-Ming GM
Oncotarget 20160501 22
The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. In this study, we found that ubiquitin associated protein 2 (UBAP2) was significantly downregulated in hepatocellular carcinoma (HCC) tissues compared with adjacent normal tissues. Furthermore, higher expression of UBAP2 in cancer tissues was correlated with good prognosis in HCC patients. Knockdown of UBAP2 significantly enhanced the invasion and proliferation of HCC cells in vitro and promoted ...[more]