Ontology highlight
ABSTRACT:
SUBMITTER: Chen Q
PROVIDER: S-EPMC5078754 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Chen Qian Q Xu Ligeng L Liang Chao C Wang Chao C Peng Rui R Liu Zhuang Z
Nature communications 20161021
A therapeutic strategy that can eliminate primary tumours, inhibit metastases, and prevent tumour relapses is developed herein by combining adjuvant nanoparticle-based photothermal therapy with checkpoint-blockade immunotherapy. Indocyanine green (ICG), a photothermal agent, and imiquimod (R837), a Toll-like-receptor-7 agonist, are co-encapsulated by poly(lactic-co-glycolic) acid (PLGA). The formed PLGA-ICG-R837 nanoparticles composed purely by three clinically approved components can be used fo ...[more]