Ontology highlight
ABSTRACT:
SUBMITTER: Pazienza V
PROVIDER: S-EPMC5078890 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Pazienza Valerio V Panebianco Concetta C Rappa Francesca F Memoli Domenico D Borghesan Michela M Cannito Sara S Oji Asami A Mazza Giuseppe G Tamburrino Domenico D Fusai Giuseppe G Barone Rosario R Bolasco Giulia G Villarroya Francesc F Villarroya Joan J Hatsuzawa Kiyotaka K Cappello Francesco F Tarallo Roberta R Nakanishi Tomoko T Vinciguerra Manlio M
Epigenetics & chromatin 20161025
<h4>Background</h4>Obesity has tremendous impact on the health systems. Its epigenetic bases are unclear. MacroH2A1 is a variant of histone H2A, present in two alternatively exon-spliced isoforms macroH2A1.1 and macroH2A1.2, regulating cell plasticity and proliferation, during pluripotency and tumorigenesis. Their role in adipose tissue plasticity is unknown.<h4>Results</h4>Here, we show evidence that macroH2A1.1 protein levels in the visceral adipose tissue of obese humans positively correlate ...[more]