Ontology highlight
ABSTRACT:
SUBMITTER: Tonby K
PROVIDER: S-EPMC5078976 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Tonby Kristian K Wergeland Ida I Lieske Nora V NV Kvale Dag D Tasken Kjetil K Dyrhol-Riise Anne M AM
BMC infectious diseases 20161024 1
<h4>Background</h4>Tuberculosis (TB) causes a major burden on global health with long and cumbersome TB treatment regimens. Host-directed immune modulating therapies have been suggested as adjunctive treatment to TB antibiotics. Upregulated cyclooxygenase-2 (COX-2)-prostaglandin E2 (PGE2) signaling pathway may cause a dysfunctional immune response that favors survival and replication of Mycobacterium tuberculosis (Mtb).<h4>Methods</h4>Blood samples were obtained from patients with latent TB (n = ...[more]