Dataset Information

Clinical significance of serum omentin-1 levels in patients with pancreatic adenocarcinoma.

ABSTRACT:

Background

Omentin is related with metabolic syndrome and obesity. Pancreatic adenocarcinoma (PA) is a lethal and obesity-linked malignancy. This study was conducted to investigate the serum levels of omentin in patients with PA and the relationship with tumor progression and known prognostic parameters.

Material and methods

Serum samples were obtained from thirty-three patients on first admission before any treatment. Age, sex and body mass index (BMI) matched 30 healthy controls were included in the analysis. Both serum omentin levels were measured using enzyme-linked immunosorbent assay (ELISA).

Results

The median age at diagnosis was 59 years (32-84 years). Twenty (61%) patients were men and the remaining were women. The most common metastatic site was liver in 23 patients with metastasis (n = 19, 83%). Thirty-nine percent of 23 metastatic patients who received palliative chemotherapy (CTx) were CTx-responsive. Median overall survival of the whole group was 41.3 ± 8.3 weeks [95% confidence interval (CI) = 25-58 weeks]. The baseline serum omentin levels were significantly higher in patients with PA than in the control group (p < 0.001). Serum omentin levels were significantly higher in patients with larger pathologic tumor size compared with smaller size (p = 0.03). Conversely, serum omentin concentration was found to have no prognostic role on survival (p = 0.54).

Conclusion

Serum levels of omentin may have a good diagnostic role in patients with PA.

SUBMITTER: Karabulut S

PROVIDER: S-EPMC5079241 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Publications

Clinical significance of serum omentin-1 levels in patients with pancreatic adenocarcinoma.

Karabulut Senem S Afsar Cigdem Usul CU Karabulut Mehmet M Alis Halil H Bozkurt Mehmet Abdussamet MA Aydogan Fatma F Serilmez Murat M Tas Faruk F

BBA clinical 20161015

<h4>Background</h4>Omentin is related with metabolic syndrome and obesity. Pancreatic adenocarcinoma (PA) is a lethal and obesity-linked malignancy. This study was conducted to investigate the serum levels of omentin in patients with PA and the relationship with tumor progression and known prognostic parameters.<h4>Material and methods</h4>Serum samples were obtained from thirty-three patients on first admission before any treatment. Age, sex and body mass index (BMI) matched 30 healthy controls ...[more]

PMID: 27785418

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Dataset Information

Clinical significance of serum omentin-1 levels in patients with pancreatic adenocarcinoma.

Background

Material and methods

Results

Conclusion

Publications

Clinical significance of serum omentin-1 levels in patients with pancreatic adenocarcinoma.

Similar Datasets

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