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Genome-wide identification of expression quantitative trait loci for human telomerase.

ABSTRACT: A genome-wide association study was conducted to identify expression quantitative trait loci (eQTL) for human telomerase.We tested the genetic associations of nucleotide variants with expression of the genes encoding human telomerase reverse transcriptase (hTERT) and telomerase RNA components (TERC) in lymphoblastoid cell lines derived from 373 Europeans.Our results revealed 6 eQTLs associated with hTERT (P?

SUBMITTER: Kim H

PROVIDER: S-EPMC5079342 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Genome-wide identification of expression quantitative trait loci for human telomerase.

Kim Hanseol H Ryu Jihye J Lee Chaeyoung C

Medicine 20161001 42

A genome-wide association study was conducted to identify expression quantitative trait loci (eQTL) for human telomerase.We tested the genetic associations of nucleotide variants with expression of the genes encoding human telomerase reverse transcriptase (hTERT) and telomerase RNA components (TERC) in lymphoblastoid cell lines derived from 373 Europeans.Our results revealed 6 eQTLs associated with hTERT (P < 5 × 10). One eQTL (rs17755753) was located in the intron 1 of the gene encoding R-spond ...[more]

PMID: 27759658

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Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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