Ontology highlight
ABSTRACT:
SUBMITTER: Zhang YH
PROVIDER: S-EPMC5079577 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zhang Yu-Hang YH Chu Chen C Wang Shaopeng S Chen Lei L Lu Jing J Kong XiangYin X Huang Tao T Li HaiPeng H Cai Yu-Dong YD
PloS one 20161025 10
A drug's biological half-life is defined as the time required for the human body to metabolize or eliminate 50% of the initial drug dosage. Correctly measuring the half-life of a given drug is helpful for the safe and accurate usage of the drug. In this study, we investigated which gene ontology (GO) terms and biological pathways were highly related to the determination of drug half-life. The investigated drugs, with known half-lives, were analyzed based on their enrichment scores for associated ...[more]