Ontology highlight
ABSTRACT:
SUBMITTER: Garcia GA
PROVIDER: S-EPMC5079698 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Garcia Giancarlo A GA Ngai Philip P Mosaed Sameh S Lin Ken Y KY
Clinical ophthalmology (Auckland, N.Z.) 20161018
Latanoprostene bunod (LBN) is a novel nitric oxide-donating prostaglandin F<sub>2α</sub> receptor agonist in clinical development for intraocular pressure lowering in open-angle glaucoma and ocular hypertension. Currently in Phase III clinical trials in the USA, European Union, and Japan, LBN has demonstrated promising efficacy while maintaining safety and tolerability. We review preclinical and clinical developmental efforts and evaluate the potential role of LBN monotherapy in the management o ...[more]