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ABSTRACT:
SUBMITTER: Nakagawa-Goto K
PROVIDER: S-EPMC5079804 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nakagawa-Goto Kyoko K Taniguchi Yukako Y Watanabe Yurie Y Oda Akifumi A Ohkoshi Emika E Hamel Ernest E Lee Kuo-Hsiung KH Goto Masuo M
Bioorganic & medicinal chemistry 20160925 22
Previously synthesized 2-(benzo[b]thiophene-3'-yl)-6,8,8-triethyldesmosdumotin B (1, TEDB-TB) and 2-(naphth-1'-yl)-6,8,8-triethyldesmosdumotin B (2) showed potent activity against multiple human tumor cell lines, including a multidrug-resistant (MDR) subline, by targeting spindle formation and/or the microtubule network. Consequently, ester analogues of hydroxylated naphthyl substituted TEBDs (3-5) were prepared and evaluated for their effects on tumor cell proliferation and on tubulin assembly. ...[more]