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Lactam Triterpenoids from the Bark of Toona sinensis.


ABSTRACT: Three new limonoid-type triterpenoids, namely toonasins A-C (1-3) with a rare lactam E ring, along with six known compounds (4-9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compounds 3 and 5 showed weak cytotoxicities.

SUBMITTER: Meng QQ 

PROVIDER: S-EPMC5080210 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Lactam Triterpenoids from the Bark of Toona sinensis.

Meng Qian-Qian QQ   Peng Xing-Rong XR   Lu Shuang-Yang SY   Wan Luo-Sheng LS   Wang Xia X   Dong Jin-Run JR   Chu Rui R   Zhou Lin L   Li Xiao-Nian XN   Qiu Ming-Hua MH  

Natural products and bioprospecting 20161018 5


Three new limonoid-type triterpenoids, namely toonasins A-C (1-3) with a rare lactam E ring, along with six known compounds (4-9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-  ...[more]

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