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Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.

ABSTRACT: Four new clerodane diterpenoids, tinosporols A-C (2-4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.

SUBMITTER: Gao Y

PROVIDER: S-EPMC5080211 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.

Gao Yuan Y Niu Yan-Fen YF Wang Fei F Hai Ping P Wang Fang F Fang Yin-Dong YD Xiong Wen-Yong WY Liu Ji-Kai JK

Natural products and bioprospecting 20161017 5

Four new clerodane diterpenoids, tinosporols A-C (2-4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-ind ...[more]

PMID: 27752986

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