Ontology highlight
ABSTRACT:
SUBMITTER: Bogomolovas J
PROVIDER: S-EPMC5080459 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Bogomolovas Julijus J Šimoliūnas Egidijus E Rinkūnaitė Ieva I Smalinskaitė Luka L Podkopajev Andrej A Bironaitė Daiva D Weis Cleo-Aron CA Marx Alexander A Bukelskienė Virginija V Gretz Norbert N Grabauskienė Virginija V Labeit Dittmar D Labeit Siegfried S
BioMed research international 20161012
<i>Background</i>. Parvovirus B19 (B19V) is a common finding in endomyocardial biopsy specimens from myocarditis and dilated cardiomyopathy patients. However, current understanding of how B19V is contributing to cardiac damage is rather limited due to the lack of appropriate mice models. In this work we demonstrate that immunization of BALB/c mice with the major immunogenic determinant of B19V located in the unique sequence of capsid protein VP1 (VP1u) is an adequate model to study B19V associat ...[more]