Ontology highlight
ABSTRACT:
SUBMITTER: Carvalho SB
PROVIDER: S-EPMC5080633 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Carvalho Sofia B SB Freire João M JM Moleirinho Mafalda G MG Monteiro Francisca F Gaspar Diana D Castanho Miguel A R B MARB Carrondo Manuel J T MJT Alves Paula M PM Bernardes Gonçalo J L GJL Peixoto Cristina C
Bioconjugate chemistry 20161007 10
Virus-like particles (VLPs) constitute a promising platform in vaccine development and targeted drug delivery. To date, most applications use simple nonenveloped VLPs as human papillomavirus or hepatitis B vaccines, even though the envelope is known to be critical to retain the native protein folding and biological function. Here, we present tagged enveloped VLPs (TagE-VLPs) as a valuable strategy for the downstream processing and monitoring of the in vivo production of specific-site-functionali ...[more]