Ontology highlight
ABSTRACT:
SUBMITTER: Templeton IE
PROVIDER: S-EPMC5080647 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20160919 10
This subteam under the Drug Metabolism Leadership Group (Innovation and Quality Consortium) investigated the quantitative role of circulating inhibitory metabolites in drug-drug interactions using physiologically based pharmacokinetic (PBPK) modeling. Three drugs with major circulating inhibitory metabolites (amiodarone, gemfibrozil, and sertraline) were systematically evaluated in addition to the literature review of recent examples. The application of PBPK modeling in drug interactions by inhi ...[more]